Commentary Cellscience Reviews Vol 4 No 2 ISSN 1742-8130

Synthetic GEFs for Rho GTPases: A strategy to unwind and assemble the signaling network to control cellular morphology

Rho family GTPases regulate the architecture of the actin cytoskeleton as part of an integrated signaling cascade that controls cellular morphology and motility. The activation of Rho GTPases is in turn regulated by a variety of highly specific guanine nucleotide exchange factors (GEFs). With the recent development of synthetic GEFs, each specifically engineered to be sensitive to a given activation stimulus, it is now possible to rewire the signaling network to finely control cellular morphology.

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