Featured Review Cellscience Reviews Vol 4 No 2 ISSN 1742-8130

Gene-Specific Control of Inflammation by TLR-induced Chromatin Modifications

Chromatin modification has been increasingly recognized as a key process by which TLR-mediated signaling controls inflammatory gene expression. Ligation of TLR leads to activation of complex intracellular signaling pathways and translocation of various transcription factors including NF-κB, STAT, and IRF. These transcription factors, among others, are capable of interacting with both sequence-specific gene promoter elements and chromatin remodeling factors or enzymes. This provides for the selection of specific genetic sequences which may be modified in order to either allow or disallow recruitment of RNA polymerase II, resulting in tightly controlled ligand-induced expression of inflammatory genes. This review will profile recent advances in this emerging area.

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