Commentary Cellscience Reviews Vol 4 No 4 ISSN 1742-8130

Alzheimer's disease amyloid plaques appear within a day

The abnormal accumulation of β-amyloid plaques in the brain is a neuropathological hallmark of Alzheimer's disease. The mechanism and time course of plaque formation in the disease are poorly understood. Recently, Bradley Hyman and colleagues presented novel data on the emergence of β-amyloid plaques in the brains of living transgenic mouse models of β-amyloidosis utilizing multiphoton microscopy. They provide novel insights into the process of β-amyloid plaque formation, including that β-amyloid plaques develop within one day.

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