 |
Commentary
Cellscience Reviews Vol 4 No 4
ISSN 1742-8130 |
|
Reciprocal regulation between voltage-gated calcium channels and calmodulin
Gerald W. Zamponi
Dept. of Physiology & Biophysics, Hotchkiss Brain Institute, University of Calgary, Canada.
Received 28th March © Cellscience 2008
Calcium entry via voltage gated calcium channels is subject to negative feedback regulation via a calcium dependent inactivation process. The features of calcium dependent inactivation vary with calcium channel subtype and are dynamically regulated by a number of cellular processes, thus allowing different types of calcium channels to respond differentially to local and global calcium rises. A recent study by Dick and colleagues identifies an intrinsic mechanism by which L-type calcium channels can regulate their own sensitivity to elevation of intracellular calcium levels.
Click 
to access complete issue ($6.49) and to download full article in 
or 
formats 