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Commentary
Cellscience Reviews Vol 4 No 4
ISSN 1742-8130 |
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Diacylglycerol Kinase δ: A pivotal player in diacylglycerol induced insulin resistance?
Guenther Boden
Dept. of Endocrinology, Diabetes & Metabolism, Temple University School of Medicine, Philadelphia, USA.
Received 23rd April © Cellscience 2008
The recent paper by Chibalin et al. contributes a new mechanism to our understanding of hyperglycemia-induced glucose toxicity. The authors show that hyperglycemia inhibits DGK-δ activity, leading to an intramyocellular accumulation of diacylglycerol which may then cause insulin resistance by modulating insulin signaling via a PKC-mediated inhibition of the IRS/PI3K/Akt pathway.
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