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Commentary
Cellscience Reviews Vol 4 No 4
ISSN 1742-8130 |
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Functional imaging during a reward prediction error task reveals psychosis
associated abnormalities in activation of VTA and its target regions
Robert Greene 1 & Patricio O’Donnell 2
1 UTSW, Department of Psychiatry, Dallas, TX &
2 University of Maryland School of Medicine,
Departments of Anatomy, Neurobiology & Psychiatry, Baltimore, MD, USA.
Received 22nd April © Cellscience 2008
A recent study by Murray, et al (2008), has examined regional CNS activation employing a task assessing reward expectation in subjects with psychosis and matched controls. Although reward prediction error was not distinguishable between these groups, there were significant differences in activation measures of regions involved in assigning salience to stimuli. These findings are consistent with pathological cognitive processing related to a lack of, or inappropriate attribution of salience.
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